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Von Willebrand Factor, Factor VIII, and Other Acute Phase Reactants as Biomarkers of Inflammation and Endothelial Dysfunction in Chronic Graft-Versus-Host Disease

dc.contributorfunder:European Commission
dc.contributorfunder:Croatian Science Foundation
dc.creatorLelas, Antonela
dc.creatorGreinix, Hildegard Theresia
dc.creatorWolff, Daniel
dc.creatorEissner, Günther
dc.creatoret al.
dc.date2021-04-30
dc.date.accessioned2024-07-16T09:01:41Z
dc.date.available2024-07-16T09:01:41Z
dc.identifierhttp://hdl.handle.net/10197/25833
dc.identifier.urihttp://hdl.handle.net/10147/642243
dc.descriptionChronic graft-versus-host disease (cGvHD) is an immune mediated late complication of allogeneic hematopoietic stem cell transplantation (alloHSCT). Discovery of adequate biomarkers could identify high-risk patients and provide an effective pre-emptive intervention or early modification of therapeutic strategy, thus reducing prevalence and severity of the disease among long-term survivors of alloHSCT. Inflammation, endothelial injury, and endothelial dysfunction are involved in cGvHD development. Altered levels of acute phase reactants have shown a strong correlation with the activity of several immune mediated disorders and are routinely used in clinical practice. Since elevated von Willebrand factor (VWF) and factor VIII (FVIII) levels have been described as acute phase reactants that may indicate endothelial dysfunction and inflammation in different settings, including chronic autoimmune diseases, they could serve as potential candidate biomarkers of cGvHD. In this review we focused on reported data regarding VWF and FVIII as well as other markers of inflammation and endothelial dysfunction, evaluating their potential role in cGvHD.
dc.descriptionnon-peer-reviewed
dc.descriptionOther
dc.languageen
dc.publisherFrontiers Media
dc.relationhttp://dx.doi.org/10.3389/fimmu.2021.676756
dc.subjectendothelial dysfunction
dc.subjectinflammation
dc.subjectFactor VIII
dc.subjectVon Willeband factor
dc.subjectchronic graft-versus-host disease (cGvHD)
dc.subjectallogeneic hematopoietic stem cell transplantation
dc.titleVon Willebrand Factor, Factor VIII, and Other Acute Phase Reactants as Biomarkers of Inflammation and Endothelial Dysfunction in Chronic Graft-Versus-Host Disease
refterms.dateFOA2024-07-16T09:01:41Z


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