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Maternal Mid-Gestation Cytokine Dysregulation in Mothers of Children with Autism Spectrum Disorder.

dc.contributor.authorCasey, S
dc.contributor.authorCarter, M
dc.contributor.authorLooney, A M
dc.contributor.authorLivingstone, V
dc.contributor.authorMoloney, G
dc.contributor.authorO'Keeffe, G W
dc.contributor.authorTaylor, R S
dc.contributor.authorKenny, L C
dc.contributor.authorMcCarthy, F P
dc.contributor.authorMcCowan, L M E
dc.contributor.authorThompson, J M D
dc.contributor.authorMurray, D M
dc.date.accessioned2024-07-17T11:19:24Z
dc.date.available2024-07-17T11:19:24Z
dc.date.issued2021-09-09
dc.identifier.pmid34505185
dc.identifier.doi10.1007/s10803-021-05271-7
dc.identifier.urihttp://hdl.handle.net/10147/642278
dc.descriptionAutism spectrum disorder (ASD) is a developmental disorder characterised by deficits in social interactions and communication, with stereotypical and repetitive behaviours. Recent evidence suggests that maternal immune dysregulation may predispose offspring to ASD. Independent samples t-tests revealed downregulation of IL-17A concentrations in cases, when compared to controls, at both 15 weeks (p = 0.02), and 20 weeks (p = 0.02), which persisted at 20 weeks following adjustment for confounding variables. This adds to the growing body of evidence that maternal immune regulation may play a role in foetal neurodevelopment.en_US
dc.language.isoenen_US
dc.rights© 2021. The Author(s).
dc.rightsAttribution 4.0 International*
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.subjectAUTISM SPECTRUM DISORDERen_US
dc.subjectcytokineen_US
dc.subjectinflammationen_US
dc.subjectMaternal immune activationen_US
dc.titleMaternal Mid-Gestation Cytokine Dysregulation in Mothers of Children with Autism Spectrum Disorder.en_US
dc.typeArticleen_US
dc.identifier.eissn1573-3432
dc.identifier.journalJournal of autism and developmental disordersen_US
dc.source.journaltitleJournal of autism and developmental disorders
dc.source.volume52
dc.source.issue9
dc.source.beginpage3919
dc.source.endpage3932
refterms.dateFOA2024-07-17T11:19:26Z
dc.source.countryIreland
dc.source.countryIreland
dc.source.countryIreland
dc.source.countryUnited States


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© 2021. The Author(s).
Except where otherwise noted, this item's license is described as © 2021. The Author(s).