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dc.contributor.authorSoliman, Osama
dc.contributor.authorAcharya, Yogesh
dc.contributor.authorGilard, Martine
dc.contributor.authorDuffy, Garry
dc.contributor.authorWijns, William
dc.contributor.authorKannan, Venkatesh
dc.contributor.authorSultan, Sherif
dc.date.accessioned2024-12-10T15:37:24Z
dc.date.available2024-12-10T15:37:24Z
dc.date.issued2024-04-09
dc.identifier.issn2297-055X
dc.identifier.pmid38660479
dc.identifier.doi10.3389/fcvm.2024.1333265
dc.identifier.urihttp://hdl.handle.net/10147/643695
dc.descriptionIntroduction Neural crest cells (NCCs) are multipotent and are attributed to the combination of complex multimodal gene regulatory mechanisms. Cardiac neural crest (CNC) cells, originating from the dorsal neural tube, are pivotal architects of the cardio-neuro-vascular domain, which orchestrates the embryogenesis of critical cardiac and vascular structures. Remarkably, while the scientific community compiled a comprehensive inventory of neural crest derivatives by the early 1980s, our understanding of the CNC's role in various cardiovascular disease processes still needs to be explored. This review delves into the differentiation of NCC, specifically the CNC cells, and explores the diverse facets of non-syndromic cardiovascular neurocristopathies. Methods A systematic review was conducted as per the PRISMA Statement. Three prominent databases, PubMed, Scopus, and Embase, were searched, which yielded 1,840 studies. We excluded 1,796 studies, and the final selection of 44 studies formed the basis of this comprehensive review. Results Neurocristopathies are a group of genetic disorders that affect the development of cells derived from the NC. Cardiovascular neurocristopathy, i.e., cardiopathy and vasculopathy, associated with the NCC could occur in the form of (1) cardiac septation disorders, mainly the aortico-pulmonary septum; (2) great vessels and vascular disorders; (3) myocardial dysfunction; and (4) a combination of all three phenotypes. This could result from abnormalities in NCC migration, differentiation, or proliferation leading to structural abnormalities and are attributed to genetic, familial, sporadic or acquired causes. Discussion Phenotypic characteristics of cardiovascular neurocristopathies, such as bicuspid aortic valve and thoracic aortic aneurysm, share a common embryonic origin and are surprisingly prevalent in the general population, necessitating further research to identify the underlying pathogenic and genetic factors responsible for these cardiac anomalies. Such discoveries are essential for enhancing diagnostic screening and refining therapeutic interventions, ultimately improving the lives of individuals affected by these conditions.en_US
dc.language.isoenen_US
dc.rights© 2024 Soliman, Acharya, Gilard, Duffy, Wijns, Kannan and Sultan.
dc.rightsAttribution 4.0 International*
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.subjectaortopathyen_US
dc.subjectbicuspid aortic valveen_US
dc.subjectcardiac neural crest cellsen_US
dc.subjectcardiac neurocristopathyen_US
dc.subjectcardiovascular neurocristopathyen_US
dc.subjectneural crest cellsen_US
dc.subjectvascular neurocristopathyen_US
dc.titleSystematic review of cardiovascular neurocristopathy-contemporary insights and future perspectives.en_US
dc.typeOtheren_US
dc.identifier.journalFrontiers in cardiovascular medicineen_US
dc.source.journaltitleFrontiers in cardiovascular medicine
dc.source.volume11
dc.source.beginpage1333265
dc.source.endpage
refterms.dateFOA2024-12-10T15:37:26Z
dc.source.countrySwitzerland


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© 2024 Soliman, Acharya, Gilard, Duffy, Wijns, Kannan and Sultan.
Except where otherwise noted, this item's license is described as © 2024 Soliman, Acharya, Gilard, Duffy, Wijns, Kannan and Sultan.