Optical fibre based real-time measurements during an LDR prostate brachytherapy implant simulation: using a 3D printed anthropomorphic phantom.

Woulfe, P; Sullivan, F J; Byrne, L; Doyle, A J; Kam, W; Martyn, M; O'Keeffe, S

dc.contributor.author	Woulfe, P
dc.contributor.author	Sullivan, F J
dc.contributor.author	Byrne, L
dc.contributor.author	Doyle, A J
dc.contributor.author	Kam, W
dc.contributor.author	Martyn, M
dc.contributor.author	O'Keeffe, S
dc.date.accessioned	2025-02-18T15:27:51Z
dc.date.available	2025-02-18T15:27:51Z
dc.date.issued	2021-05-27
dc.identifier.pmid	34045648
dc.identifier.doi	10.1038/s41598-021-90880-6
dc.identifier.uri	http://hdl.handle.net/10147/644368
dc.description	An optical fibre sensor based on radioluminescence, using the scintillation material terbium doped gadolinium oxysulphide (Gd2O2S:Tb) is evaluated, using a 3D printed anthropomorphic phantom for applications in low dose-rate (LDR) prostate brachytherapy. The scintillation material is embedded in a 700 µm diameter cavity within a 1 mm plastic optical fibre that is fixed within a brachytherapy needle. The high spatial resolution dosimeter is used to measure the dose contribution from Iodine-125 (I-125) seeds. Initially, the effects of sterilisation on the sensors (1) repeatability, (2) response as a function of angle, and (3) response as a function of distance, are evaluated in a custom polymethyl methacrylate phantom. Results obtained in this study demonstrate that the output response of the sensor, pre- and post-sterilisation are within the acceptable measurement uncertainty ranging from a maximum standard deviation of 4.7% pre and 5.5% post respectively, indicating that the low temperature sterilisation process does not damage the sensor or reduce performance. Subsequently, an LDR brachytherapy plan reconstructed using the VariSeed treatment planning system, in an anthropomorphic 3D printed training phantom, was used to assess the suitability of the sensor for applications in LDR brachytherapy. This phantom was printed based on patient anatomy, with the volume and dimensions of the prostate designed to represent that of the patient. I-125 brachytherapy seeds, with an average activity of 0.410 mCi, were implanted into the prostate phantom under trans-rectal ultrasound guidance; following the same techniques as employed in clinical practice by an experienced radiation oncologist. This work has demonstrated that this sensor is capable of accurately identifying when radioactive I-125 sources are introduced into the prostate via a brachytherapy needle.	en_US
dc.language.iso	en	en_US
dc.rights	Attribution 4.0 International	*
dc.rights.uri	http://creativecommons.org/licenses/by/4.0/	*
dc.title	Optical fibre based real-time measurements during an LDR prostate brachytherapy implant simulation: using a 3D printed anthropomorphic phantom.	en_US
dc.type	Article	en_US
dc.identifier.eissn	2045-2322
dc.identifier.journal	Scientific reports	en_US
dc.source.journaltitle	Scientific reports
dc.source.volume	11
dc.source.issue	1
dc.source.beginpage	11160
dc.source.endpage
refterms.dateFOA	2025-02-18T15:27:53Z
dc.source.country	England