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The Acute Effect of Magnesium Supplementation on Endothelial Function: A Randomized Cross-Over Pilot Study.

dc.contributor.authorMurphy, Caitríona
dc.contributor.authorByrne, Jennifer
dc.contributor.authorKeogh, Jennifer B
dc.contributor.authorHeadland, Michelle L
dc.contributor.authorClifton, Peter M
dc.date.accessioned2025-04-22T09:55:36Z
dc.date.available2025-04-22T09:55:36Z
dc.date.issued2021-05-17
dc.identifier.pmid34067524
dc.identifier.doi10.3390/ijerph18105303
dc.identifier.urihttp://hdl.handle.net/10147/644917
dc.descriptionMagnesium (Mg) deficiency might be a catalyst in the process of endothelial dysfunction, an early event in the pathogenesis of atherosclerosis. The aim of this study was to determine the acute effect of an oral Mg supplement as compared to control on endothelial function assessed by flow-mediated dilatation (FMD). Nineteen participants (39 years, body mass index (BMI) 22.9 kg/m2) completed this randomized cross-over study. Blood pressure (BP) and FMD were measured and blood samples were taken before participants drank 200 mL water, with or without an over the counter Mg supplement (450 mg and 300 mg for men and women). Measurements were repeated at 60 and 120 min. There was a statistically significant two-way interaction between treatment and time on serum Mg (p = 0.037). A difference of -0.085 mm in FMD was observed 60-min post drink in the control group, as compared to baseline FMD, and no difference was observed in the supplement group as compared to baseline. Despite the non-significant interaction between treatment and time on FMD, once adjusted for baseline, the difference seen in the control group and the lack of change in the supplement group at 60 min post-drink suggests that Mg might attenuate the reduction in FMD post-prandially.en_US
dc.language.isoenen_US
dc.rightsAttribution 4.0 International*
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.subjectendothelial functionen_US
dc.subjectflow mediated dilatation 2en_US
dc.subjectmagnesium 1en_US
dc.titleThe Acute Effect of Magnesium Supplementation on Endothelial Function: A Randomized Cross-Over Pilot Study.en_US
dc.typeArticleen_US
dc.identifier.eissn1660-4601
dc.identifier.journalInternational journal of environmental research and public healthen_US
dc.source.journaltitleInternational journal of environmental research and public health
dc.source.volume18
dc.source.issue10
refterms.dateFOA2025-04-22T09:55:37Z
dc.source.countrySwitzerland


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Attribution 4.0 International
Except where otherwise noted, this item's license is described as Attribution 4.0 International