• MicroRNA-34a is a potent tumor suppressor molecule in vivo in neuroblastoma.

      Tivnan, Amanda; Tracey, Lorraine; Buckley, Patrick G; Alcock, Leah C; Davidoff, Andrew M; Stallings, Raymond L; Department of Cancer Genetics, Royal College of Surgeons in Ireland, York House, York Street, Dublin 2, Ireland. (2011)
      Neuroblastoma is a paediatric cancer which originates from precursor cells of the sympathetic nervous system and accounts for 15% of childhood cancer mortalities. With regards to the role of miRNAs in neuroblastoma, miR-34a, mapping to a chromosome 1p36 region that is commonly deleted, has been found to act as a tumor suppressor through targeting of numerous genes associated with cell proliferation and apoptosis.