• Ensemble approach combining multiple methods improves human transcription start site prediction.

      Dineen, David G; Schröder, Markus; Higgins, Desmond G; Cunningham, Pádraig; Complex and Adaptive Systems Laboratory (CASL), University College Dublin, Belfield, Dublin 4, Ireland. david.dineen@ucd.ie (2010)
      The computational prediction of transcription start sites is an important unsolved problem. Some recent progress has been made, but many promoters, particularly those not associated with CpG islands, are still difficult to locate using current methods. These methods use different features and training sets, along with a variety of machine learning techniques and result in different prediction sets.