• Preoperative neutrophil response as a predictive marker of clinical outcome following open heart surgery and the impact of leukocyte filtration.

      Soo, Alan W; Maher, Belinda M; Daly, Liam; Wood, Alfred E; Watson, William R; Prof. Eoin O'Malley National Centre for Cardiothoracic Surgery, Mater Misericordiae University Hospital, UCD School of Medicine and Medical Sciences, UCD Conway Institute of Biomolecular and Biomedical Research, University College Dublin, Eccle Street, Dublin, Ireland. alan.soo@ucd.ie (2010-11)
      Open heart surgery is associated with a massive systemic inflammatory response. Neutrophils, are the main mediator of this response. We hypothesised that the degree of neutrophil activation and inflammatory response to open heart surgery varies individually and correlates with clinical outcome. The aim of this study was to determine if individual clinical outcome can be predicted preoperatively through assessment of in-vitro stimulated neutrophil responses. Following that, the effects of neutrophil depletion through leukocyte filters are examined.