• Health promoting school indicators: schematic models from students

      Nic Gabhainn, Saoirse; Sixsmith, Jane; Delaney, Ellen Nora; Moore, Miriam; O'Higgins, Siobhan; Inchley, Jo; Health Promotion Research Centre, Department of Health Promotion, NUI Galway, Child and Adolescent Health Research Unit, University of Edinburgh, Scotland. (Emerald, 2007)
    • Health risk profile of prostitutes in Dublin.

      McDonnell, R J; McDonnell, P M; O'Neill, M; Mulcahy, F; Health Information Unit, Eastern Health Board, Dr Steeven's Hospital, Dublin, Ireland. (1998-08)
      This study examined the health risk profile of prostitutes in Dublin. Clinical records of all 150 new prostitutes who attended a drop-in clinic for prostitutes in Dublin city during the period 1991-1997 were reviewed. Variables examined included: age, use of injectable drugs, human immunodeficiency virus (HIV) status, hepatitis B and C status, presence of sexually transmitted disease (STD), cervical cytology. Results showed the mean age of the women was 32 years. Among those tested, 2.5% were HIV positive, 5% were hepatitis B positive, 8% were hepatitis C positive and 25% had an STD. Almost 8% were injecting drug users (IDU) with higher prevalences of HIV, hepatitis B and C compared with non-IDU (P < 0.001). The clinic has been successful in providing a health-care facility for the specific health needs of this patient cohort.
    • Healthcare utilisation among cancer survivors over 50 years of age

      Coughlan, D; Doherty, E; Frick, K; Ward, P; O’Neill, C (Irish Medical Journal, 2016-02)
    • A Healthy Change

      Council for the Status of Women.; Dublin Well Womans Centre (1993)
    • Heart failure in Ireland: epidemiology and economic implications

      Sugrue, D; University College Dublin. Graduate School of Business. Centre for Health Economics (University College Dublin. Graduate School of Business for Publication in the Forum, the Journal of the Irish College of General Practitioners, 1994-03)
    • HeartBeat--improving heart attack care

      Jennings, S; Bennett, K; Cavanagh, B; Health Service Executive (HSE), Dr. Steevens' Hospital (Irish Medical Journal, 2011-01)
    • A heavy heart; A massive right atrial myxoma causing fatigue and shortness of breath.

      Leonard, S; Ryan, J; The Emergency Department, St Vincent's University Hospital, Elm Park, Dublin 4. simon.j.leonard@gmail.com (2010-03)
      Cardiac myxomas are rare. The clinical diagnosis of an atrial myxoma may occur in an asymptomatic patient but may also present with cardiac failure, syncope, arrythmias, or with vascular evidence of tumour embolisation. The delay in diagnosis from presentation is approximately ten months. We present the case of a 53-year-old woman who attended our Emergency Department with dyspnoea, fatigue and left sided chest pain. Investigations revealed a massive right atrial myxoma. The tumour was resected successfully. Emergency Physicians should be aware of the subtle ways in which an atrial myxoma can present because of the potential for fatal outcomes.
    • Helicobacter Pylori eradication therapy: getting research into practice.

      McDonnell, R; O'Morain, C; Boland, M; Culhane, A; Johnson, Z; Johnson, H; Murray, F; Doyle, D; Eastern Regional Health Authority, Health Information Unit, Department of Public Health, Dr Steeven's Hospital, Dublin 8, Ireland. bob.mcdonnell@erha.ie (2003-01)
      Helicobacter Pylori (H. Pylori) is the primary cause of duodenal ulcer (DU). Guidelines recommend that all patients with DU be considered for Helicobacter Pylori Eradication Therapy (HPET). However, the proportion of patients with DU on long term anti-ulcer medication receiving HPET is small. This study examined the effectiveness of the continuing medical education (CME) network of the Irish College of General Practitioners (ICGP) in promoting best practice in DU treatment among GPs in an eastern region of Ireland. Ninty eight GPs recruited from the CME network of the ICGP were randomised in two cohorts. Cohort 1 received an (early) intervention; GPs were asked to identify their patients with DU receiving long term anti-ulcer medication and prescribe HPET according to defined criteria. Cohort 2 received the intervention later. Prescribing of HPET was monitored using routine prescribing data. Twenty per cent (286/1,422) of patients in cohort 1 and 19.2% (127/661) in cohort 2 had a DU. After exclusions, 53% (152/286) in cohort 1 and 30.7% (39/127) in cohort 2, were eligible for HPET. A significantly higher proportion of patients in cohort 1 received HPET compared with cohort 2 during the early intervention period (13.8% vs 0.0%, p<0.05). Reasons for not prescribing HPET included concurrent illness in patients, failure to comply with treatment. Best practice guidelines on HPET treatment of DU can be successfully applied using CME networks. This model could be repeated in another therapeutic area where established research is not yet current practice.
    • Helpful and unhelpful aspects of eating disorders treatment involving psychological therapy: a meta-synthesis of qualitative research studies.

      Timulak L; Buckroyd J; Klimas J; Creaner M; Wellsted D; Bunn F; Broadshaw S; Green G (British Association for Counselling & Psychotherapy, 2013)
    • Herbal medicine--sets the heart racing!

      McGovern, E; McDonnell, T J (2010-07)
      The potential for pharmaceuticals to produce side effects and drug interactions is well known to medical practitioners and the lay public alike. However, the potential for alternative medicines to produce such effects is less widely known. We describe a potentially dangerous interaction between a herbal medicine and concomitant selective serotonin re-uptake inhibitor (SSRI) ingestion.
    • Heritability in the efficiency of nonsense-mediated mRNA decay in humans.

      Seoighe, Cathal; Gehring, Chris; School of Mathematics, Statistics and Applied Mathematics, National University of Ireland Galway, Galway, Ireland. Cathal.Seoighe@nuigalway.ie (2010)
      BACKGROUND: In eukaryotes mRNA transcripts of protein-coding genes in which an intron has been retained in the coding region normally result in premature stop codons and are therefore degraded through the nonsense-mediated mRNA decay (NMD) pathway. There is evidence in the form of selective pressure for in-frame stop codons in introns and a depletion of length three introns that this is an important and conserved quality-control mechanism. Yet recent reports have revealed that the efficiency of NMD varies across tissues and between individuals, with important clinical consequences. PRINCIPAL FINDINGS: Using previously published Affymetrix exon microarray data from cell lines genotyped as part of the International HapMap project, we investigated whether there are heritable, inter-individual differences in the abundance of intron-containing transcripts, potentially reflecting differences in the efficiency of NMD. We identified intronic probesets using EST data and report evidence of heritability in the extent of intron expression in 56 HapMap trios. We also used a genome-wide association approach to identify genetic markers associated with intron expression. Among the top candidates was a SNP in the DCP1A gene, which forms part of the decapping complex, involved in NMD. CONCLUSIONS: While we caution that some of the apparent inter-individual difference in intron expression may be attributable to different handling or treatments of cell lines, we hypothesize that there is significant polymorphism in the process of NMD, resulting in heritable differences in the abundance of intronic mRNA. Part of this phenotype is likely to be due to a polymorphism in a decapping enzyme on human chromosome 3.
    • Heterogeneity of existing research relating to sexual violence, sexual assault and rape precludes meta-analysis of injury data.

      Kennedy, Kieran M; Galway Sexual Assault Treatment Unit, Health Service Executive West, Hazelwood House, Parkmore Road, Galway, Ireland; Room 203, Cummerford Medical Education Centre, Clinical Science Institute, National University of Ireland, Galway, Ireland. Electronic address: kieran.m.kennedy@gmail.com. (2013-07)
      In order for medical practitioners to adequately explain to the court the findings of their clinical examinations of victims of sexual violence, they must have access to research data which will place their findings in to context. Unfortunately, existing research has reported a very wide range of injury prevalence data. This papers aims to provide an explanation for this wide variation in results and, furthermore, this paper aims to establish if it is possible to carry out a meta-analysis of existing research data, pertaining to the prevalence of injury after sexual assault. It is suggested that pooling of individual study results may allow statistically robust determination of the true prevalence of injury in victims of sexual violence. It is concluded that heterogeneity in research methodology, between existing research studies, is responsible for the broad range of reported prevalence rates. Finally, this heterogeneity is seen to preclude robust meta-analysis.
    • High DNA melting temperature predicts transcription start site location in human and mouse.

      Dineen, David G; Wilm, Andreas; Cunningham, Pádraig; Higgins, Desmond G; Complex and Adaptive Systems Laboratory (CASL), University College Dublin, Belfield, Dublin 4, Ireland. david.dineen@ucd.ie (2009-12)
      The accurate computational prediction of transcription start sites (TSS) in vertebrate genomes is a difficult problem. The physicochemical properties of DNA can be computed in various ways and a many combinations of DNA features have been tested in the past for use as predictors of transcription. We looked in detail at melting temperature, which measures the temperature, at which two strands of DNA separate, considering the cooperative nature of this process. We find that peaks in melting temperature correspond closely to experimentally determined transcription start sites in human and mouse chromosomes. Using melting temperature alone, and with simple thresholding, we can predict TSS with accuracy that is competitive with the most accurate state-of-the-art TSS prediction methods. Accuracy is measured using both experimentally and manually determined TSS. The method works especially well with CpG island containing promoters, but also works when CpG islands are absent. This result is clear evidence of the important role of the physical properties of DNA in the process of transcription. It also points to the importance for TSS prediction methods to include melting temperature as prior information.
    • High prevalence of dementia among community dwelling older adults in receipt of state funded home care packages: implications for health care planning

      O’Brien, I.; Smuts, K.; Fan, C. W.; O’Sullivan, M.; Warters, A. (Cambridge Journals, 2017-12-22)
      Objectives The majority of people living with dementia in Ireland reside in their own homes, some supported by formal or informal home care. This audit aimed to estimate the prevalence of dementia and suspected cognitive impairment (CI) among older adults, 65+ years, in receipt of formal home care (domiciliary care) in a defined health service area in North Dublin. A secondary objective of the audit was to explore factors associated with dementia or CI in this cohort. Methods A cross-sectional audit was conducted on all clients aged 65+ years actively receiving publicly funded home care packages (HCPs) during May 2016 in Healthcare Service Executive CHO9 Dublin North Central. A total of 935 urban community dwelling older adults were included in the study [mean age 83.7 ( s.d. 7.4) years and 65% female]. Basic socio-demographic and health data were extracted from common summary assessment reports. Service users were categorised as having (a) dementia if a diagnosis of dementia or cognitive decline which impacts on independent living, was documented by a health professional or (b) suspected CI where a validated cognitive screening tool was applied and the score was indicative of mild CI. Results Overall, the estimated prevalence of dementia and suspected CI was 37.1% and 8.7%, respectively. Factors significantly associated with dementia and suspected CI were higher dependency and home care hours, communication difficulty and being non-self-caring ( p <0.001). Notably, half (51.6%) of those with either dementia or suspected CI group lived alone. Conclusions Our findings suggest a high prevalence dementia among HCP users, highlighting a need and opportunity for dementia-specific approaches to support older people in their homes.