Now showing items 1-20 of 33403

    • Referral patterns for specialist child and adolescent mental health services in the Republic of Ireland during the COVID-19 pandemic compared with 2019 and 2018.

      mcnicholas, fiona; Kelleher, Ian; Hedderman, Elma; Lynch, Fionnuala; Healy, Elaine; Thornton, Therese; Barry, Edwina; Kelly, Lisa; McDonald, James; Holmes, Keith; et al. (2021-05-03)
    • Emerging from emergency pandemic pedagogy: A survey of anatomical educators in the United Kingdom and Ireland.

      Dulohery, Kate; Scully, Deirdre; Longhurst, Georga J; Stone, Danya M; Campbell, Thomas (2021-05-26)
    • Resistance to COVID-19 vaccination has increased in Ireland and the United Kingdom during the pandemic.

      Hyland, P; Vallières, F; Shevlin, M; Bentall, R P; McKay, R; Hartman, T K; McBride, O; Murphy, J (2021-04-27)
    • A randomised, double-blind, placebo-controlled, pilot trial of intravenous plasma purified alpha-1 antitrypsin for SARS-CoV-2-induced Acute Respiratory Distress Syndrome: a structured summary of a study protocol for a randomised, controlled trial.

      McEvoy, Natalie L; Clarke, Jennifer L; Mc Elvaney, Oliver J; Mc Elvaney, Oisin F; Boland, Fiona; Hyland, Deirdre; Geoghegan, Pierce; Donnelly, Karen; Friel, Oisin; Cullen, Ailbhe; et al. (2021-04-19)
      The study will be conducted in Intensive Care Units in hospitals across Ireland. Patients with a laboratory-confirmed diagnosis of SARS-CoV-2-infection, moderate to severe ARDS (meeting Berlin criteria for a diagnosis of ARDS with a PaO2/FiO2 ratio <200 mmHg), >18 years of age and requiring invasive or non-invasive mechanical ventilation. All individuals meeting any of the following exclusion criteria at baseline or during screening will be excluded from study participation: more than 96 hours has elapsed from onset of ARDS; age < 18 years; known to be pregnant or breastfeeding; participation in a clinical trial of an investigational medicinal product (other than antibiotics or antivirals) within 30 days; major trauma in the prior 5 days; presence of any active malignancy (other than nonmelanoma skin cancer) which required treatment within the last year; WHO Class III or IV pulmonary hypertension; pulmonary embolism prior to hospital admission within past 3 months; currently receiving extracorporeal life support (ECLS); chronic kidney disease receiving dialysis; severe chronic liver disease with Child-Pugh score > 12; DNAR (Do Not Attempt Resuscitation) order in place; treatment withdrawal imminent within 24 hours; Prisoners; non-English speaking patients or those who do not adequately understand verbal or written information unless an interpreter is available; IgA deficiency.
    • Conceptualising household food insecurity in Northern Ireland: risk factors, implications for society and the economy, and recommendations for business and policy response.

      Beacom, Emma; Furey, Sinéad; Hollywood, Lynsey; Humphreys, Paul (2021-04-26)
      Household food insecurity in developed nations has been identified as a significant public health concern. Although various research on the topic exists, such as contributors to food insecurity, and implications for individual physical and mental health outcomes; there is currently a lack of consideration as to how individual implications of food insecurity such as poor physical and mental health can consequently impact on business and the wider economy. In addition, there is a lack of conceptual literature related to food insecurity. Stakeholder interviews (n = 19) were conducted, and data were used to inform the conceptual model (risk factors, potential implications for individuals, the economy and business, and opportunities for business and policy response). The main suggested implications related to business and the economy were reduced contribution to the workforce and the economy, and increased cost pressures on the National Health Service. Business responses suggested included the inclusion of initiatives to address food insecurity in corporate social responsibility strategies, and further involvement of food businesses/retailers in redistributing surplus food. Policy responses suggested included policies relating to welfare, wages and work contracts, food redistribution incentives, sustainability, and community interventions in disadvantaged areas. The resulting model is unique in conceptualising food insecurity in the Northern Ireland context, with applicability to the UK and other developed nations.
    • Chemical Exposure: European Citizens' Perspectives, Trust, and Concerns on Human Biomonitoring Initiatives, Information Needs, and Scientific Results.

      Health Service Executive (HSE); Uhl, Maria; Santos, Ricardo R; Costa, Joana; Santos, Osvaldo; Virgolino, Ana; Evans, David S; Murray, Cora; Mulcahy, Maurice; Ubong, Dorothy; et al. (2021-02-05)
    • Feasibility of a Broad Test Battery to Assess Physical Functioning Limitations of People Experiencing Homelessness.

      Broderick, Julie; Kiernan, Sinead; Murphy, Niamh; Dowds, Joanne; Ní Cheallaigh, Cliona (2021-01-25)
      The completion rate varied: 65% (Short Physical Performance Battery), 55.4% (timed up and go), 38% (six-minute walk test), 31% (stair climb test), 97% (Clinical Frailty Scale), 75% (handgrip dynamometer), 74% (calf circumference measurement)). Collectively, the most common reasons for test non-participation were pain (24.1%, n = 40), not feeling well or able enough (20.1%, n = 33), and declined (11%, n = 18).
    • A national evaluation of the Irish public health counselling in primary care service- examination of initial effectiveness data.

      Brand, Charles; Ward, Fiona; MacDonagh, Niamh; Cunningham, Sharon; Timulak, Ladislav (2021-05-03)
    • To Adapt or Not to Adapt: The Association between Implementation Fidelity and the Effectiveness of Diabetes Self-Management Education.

      Schinckus, Louise; Van den Broucke, Stephan; van der Zanden, Gerard; Levin-Zamir, Diane; Mueller, Gabriele; Riemenschneider, Henna; Hayter, Victoria; Yardley, Lucy; Schillinger, Dean; Doyle, Gerardine; et al. (2021-04-13)
    • Rolling review of International Public Health Guidance in relation to the Omicron variant (B.1.1.529) [v5.0]

      Health Information and Quality Authority (HIQA) (Health Information and Quality Authority (HIQA), 2022-01-25)
    • Grace Under Pressure: Resilience, Burnout, and Wellbeing in Frontline Workers in the United Kingdom and Republic of Ireland During the SARS-CoV-2 Pandemic.

      Sumner, Rachel C; Kinsella, Elaine L (2021-01-27)
      The coronavirus pandemic has necessitated extraordinary human resilience in order to preserve and prolong life and social order. Risks to health and even life are being confronted by workers in health and social care, as well as those in roles previously never defined as "frontline," such as individuals working in community supply chain sectors. The strategy adopted by the United Kingdom (UK) government in facing the challenges of the pandemic was markedly different from other countries. The present study set out to examine what variables were associated with resilience, burnout, and wellbeing in all sectors of frontline workers, and whether or not these differed between the UK and Republic of Ireland (RoI). Individuals were eligible if they were a frontline worker (in health and social care, community supply chain, or other emergency services) in the UK or RoI during the pandemic. Part of a larger, longitudinal study, the participants completed an online survey to assess various aspects of their daily and working lives, along with their attitudes toward their government's handling of the crisis, and measurement of psychological variables associated with heroism (altruism, meaning in life, and resilient coping). A total of 1,305 participants (N = 869, 66.6% from the UK) provided sufficient data for analysis. UK-based workers reported lower wellbeing than the RoI-based participants. In multivariate models, both psychological and pandemic-related variables were associated with levels of resilience, burnout, and wellbeing in these workers, but which pandemic-related variables were associated with outcomes differed depending on the country. The judgment of lower timeliness in their government's response to the pandemic appeared to be a key driver of each outcome for the UK-based frontline workers. These findings provide initial evidence that the different strategies adopted by each country may be associated with the overall wellbeing of frontline workers, with higher detriment observed in the UK. The judgment of the relatively slow response of the UK government to instigate their pandemic measures appears to be associated with lower resilience, higher burnout, and lower wellbeing in frontline workers in the UK.
    • Target 5000: a standardized all-Ireland pathway for the diagnosis and management of inherited retinal degenerations.

      Stephenson, Kirk A J; Zhu, Julia; Wynne, Niamh; Dockery, Adrian; Cairns, Rebecca M; Duignan, Emma; Whelan, Laura; Malone, Conor P; Dempsey, Hilary; Collins, Karen; et al. (2021-05-05)
      Introduction: Inherited retinal degenerations (IRD) are rare genetic disorders with > 300 known genetic loci, manifesting variably progressive visual dysfunction. IRDs were historically underserved due to lack of effective interventions. Many novel therapies will require accurate diagnosis (phenotype and genotype), thus an efficient and effective pathway for assessment and management is required. Methods: Using surveys of existing practice patterns and advice from international experts, an all-Ireland IRD service (Target 5000) was designed. Detailed phenotyping was followed by next generation genetic sequencing in both a research and accredited laboratory. Unresolved pedigrees underwent further studies (whole gene/whole exome/whole genome sequencing). Novel variants were interrogated for pathogenicity (cascade screening, in silico analysis, functional studies). A multidisciplinary team (MDT; ophthalmologists, physicians, geneticists, genetic counsellors) reconciled phenotype with genotype. A bespoke care plan was created for each patient comprising supports, existing interventions, and novel therapies/clinical trials. Results and discussion: Prior to Target 5000, a significant cohort of patients were not engaged with healthcare/support services due to lack of effective interventions. Pathogenic or likely pathogenic variants in IRD-associated genes were detected in 62.3%, with 11.6% having variants of unknown significance. The genotyping arm of Target 5000 allowed a 42.73% cost saving over independent testing, plus the value of MDT expertise/processing. Partial funding has transferred from charitable sources to government resources. Conclusion: Target 5000 demonstrates efficacious and efficient clinical/genetic diagnosis, while discovering novel IRD-implicated genes/variants and investigating mechanisms of disease and avenues of intervention. This model could be used to develop similar IRD programmes in small/medium-sized nations.
    • Understanding disadvantaged adolescents' perception of health literacy through a systematic development of peer vignettes.

      Goss, Hannah R; McDermott, Clare; Hickey, Laura; Issartel, Johann; Meegan, Sarah; Morrissey, Janis; Murrin, Celine; Peers, Cameron; Smith, Craig; Spillane, Ailbhe; et al. (2021-03-25)
    • Geocoding cryptosporidiosis cases in Ireland (2008-2017)-development of a reliable, reproducible, multiphase geocoding methodology.

      Health Protection Surveillance Centre; Domegan, Lisa; Garvey, Patricia; McKeown, Paul; Johnson, Howard; Hynds, Paul; O'Dwyer, Jean; ÓhAiseadha, Coilín (Health Service Executive, 2021-01-19)
    • Successful maintenance of process and outcomes for oesophageal cancer surgery in Ireland during the first wave of the COVID-19 pandemic.

      Bolger, Jarlath C; Donlon, Noel E; Butt, Waqas; Neary, Colm; Al Azzawi, Mohammed; Brett, Orla; King, Sinead; Downey, Eithne; Arumugasamy, Mayilone; Murphy, Thomas; et al. (2021-03-16)
      Introduction: The emergence of the novel coronavirus Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) and the coronavirus disease COVID-19 has impacted enormously on non-COVID-19-related hospital care. Curtailment of intensive care unit (ICU) access threatens complex surgery, particularly impacting on outcomes for time-sensitive cancer surgery. Oesophageal cancer surgery is a good example. This study explored the impact of the pandemic on process and short-term surgical outcomes, comparing the first wave of the pandemic from April to June in 2020 with the same period in 2019. Methods: Data from all four Irish oesophageal cancer centres were reviewed. All patients undergoing resection for oesophageal malignancy from 1 April to 30 June inclusive in 2020 and 2019 were included. Patient, disease, and peri-operative outcomes (including COVID-19 infection) were compared. Results: In 2020, 45 patients underwent oesophagectomy, and 53 in the equivalent period in 2019. There were no differences in patient demographics, co-morbidities, or use of neoadjuvant therapy. The median time to surgery from neoadjuvant therapy was 8 weeks in both 2020 and 2019. There were no significant differences in operative interventions between the two time periods. There was no difference in operative morbidity in 2020 and 2019 (28% vs 40%, p = 0.28). There was no in-hospital mortality in either period. No patient contracted COVID-19 in the perioperative period. Conclusions: Continuing surgical resection for oesophageal cancer was feasible and safe during the COVID-19 pandemic in Ireland. The national response to this threat was therefore successful by these criteria in the curative management of oesophageal cancer.
    • Comparison of barriers and facilitators of MIND diet uptake among adults from Northern Ireland and Italy.

      Timlin, Deirdre; Giannantoni, Barbara; McCormack, Jacqueline M; Polito, Angela; Ciarapica, Donatella; Azzini, Elena; Giles, Melanie; Simpson, Ellen E A (2021-02-02)
    • Funders' responsibility to ensure value in research: a self-audit by the Health Research Board Ireland.

      Cody, Anne; Hiney, Maura; Clarke, Patricia; O'Driscoll, Mairead (2021-07-29)