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Gastrointestinal Symptoms in Autism Spectrum Disorder: A Systematic Review.
Health Service Executive (HSE) Leader, Geraldine Abberton, Cathal Cunningham, Stephen Gilmartin, Katie Grudzien, Margo Higgins, Emily Joshi, Lokesh Whelan, Sally Mannion, Arlene
Health Service Executive (HSE)
Leader, Geraldine
Abberton, Cathal
Cunningham, Stephen
Gilmartin, Katie
Grudzien, Margo
Higgins, Emily
Joshi, Lokesh
Whelan, Sally
Mannion, Arlene
Advisors
Editors
Other Contributors
Departments
Date
01/04/2022
Date Submitted
Keywords
CHILD
CHILD HEALTH
autism spectrum disorders
autism symptoms
challenging behavior
comorbidity
gastrointestinal symptoms
language and communication
PSYCHOPATHOLOGY
regression
sensory issues
Severity
sleep problems
CHILD HEALTH
autism spectrum disorders
autism symptoms
challenging behavior
comorbidity
gastrointestinal symptoms
language and communication
PSYCHOPATHOLOGY
regression
sensory issues
Severity
sleep problems
Other Subjects
Subject Mesh
Planned Date
Start Date
Collaborators
Principal Investigators
Files
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nutrients-14-01471.pdf
Adobe PDF, 499.68 KB
Alternative Titles
Publisher
Abstract
This systematic review aims to offer an updated understanding of the relationship between gastrointestinal symptoms (GIS) and autism spectrum disorder (ASD) in children and adolescents. The databases PsycINFO, Medline, Cinahl, and ERIC were searched using keywords, and relevant literature was hand-searched. Papers (n = 3319) were systematically screened and deemed eligible if they were empirical studies published in English since 2014 and measured the GIS of individuals with ASD who were under 18 years old. Thirty studies were included in the final review. The study findings were synthesized under eight themes, including the prevalence and nature of GIS and their relationship with developmental regression, language and communication, ASD severity, challenging behavior, comorbid psychopathology, sleep problems, and sensory issues. The review found that GIS were common and that there was contradictory evidence concerning their relationship with co-occurring conditions. It also identified evidence of some causal relationships that support the existence of the gut-immune-brain pathways. Future research needs to use large prospective designs and objective and standardized GIS measurements to provide a nuanced understanding of GIS in the context of ASD.
Language
en
Citation
ISSN
eISSN
2072-6643
ISBN
DOI
10.3390/nu14071471
PMID
35406084